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GHRP-6 Digestive Health Research


The subject of this article will revolve around GHRP-6 peptide and research on digestive health.

Studies suggest one synthetic peptide created to potentially stimulate the production and regulate growth hormone levels is called growth hormone-releasing hexapeptide-6 (GHRP-6). GHRP-6 is a synthetic peptide with a low molecular weight that has shown potential in studies of growth hormone stimulation.

The original goal of creating growth hormone-releasing peptides (GHRP) was to create a substance that would function similarly to growth hormone-releasing hormones (GHRHs). In 1984, when scientists first identified GHRH, they speculated that the chemicals could have different functions, with GHRPs showing an apparent propensity to connect with ghrelin receptors [ii]. Scientists believe GHRPs, like the naturally occurring hormone ghrelin, seem to control activity by stimulating the hypothalamus, which might affect metabolic and nutritional processes.


In order to learn whether GHRP-6 needs endogenous GHRH presence to exhibit its potential, studies were done. In one clinical trial [iii], nine subjects aged 20 to 30 were randomly assigned to receive either a GHRH antagonist or saline, following which they were given GHRP-6 20 minutes later. Over the next hours, blood samples were taken at regular intervals to analyze growth hormone levels. Researchers suggested that subjects who were given a GHRH antagonist seemed to have lower levels of HGH than those who were given a placebo. They speculate that GHRP-6’s putative action may need endogenous GHRH.


Although GHRP-6’s mechanism is still being investigated [iii], studies have suggested that GHRPs may act by binding with two receptors: GHS-R1a and CD36. By binding with CD36 receptors, GHRP-6 may stimulate prosurvival cellular pathways [i] and potentially increase HGH secretion. The circumstances are still being looked into.

Prior speculation suggested that GHRP-6 could have a dual mode of action, affecting both the pituitary gland and the hypothalamus. The mechanism of action was explored in a group of 23 subjects, including 12 with hypothalamic-pituitary disconnection and 11 controls, in research [iv]. Subjects received either GHRH, GHRP-6, or both agents.

All 23 subjects had their HGH levels checked after the presentation. The subjects in the control group who received both GHRH and GHRP-6 seemed to have the highest HGH levels, followed by the GHRP-6 subjects and the GHRH subjects. However, in subjects with hypothalamic-pituitary disconnection, the opposite proved true: those given both GHRP-6 and GHRH appeared to have the lowest amounts of HGH. Subjects given GHRH appeared to have the same levels of HGH as controls, while subjects given GHRP-6 alone reportedly had lower HGH levels. Researchers hypothesized that GHRP-6 acted on the hypothalamic-pituitary axis to generate its potential and that GHRP-6 activity may be largely produced in the presence of GHRH.

GHRP-6 Peptide and the Thyroid

When the thyroid gland is underactive, there is less secretion of growth hormone. The primary objective of this research [v] was to assess the feasibility of using GHRP-6, a putative HGH release-boosting substance, to offset the action of natural HGH decline. Hypothyroid subjects were randomly assigned to receive one of three GHRH and GHRP-6 concentrations.

After the study, the researchers speculated that subjects given either GHRP-6 alone or a combination of GHRP-6 and GHRH seemed to induce significantly higher levels of growth hormones than subjects given GHRH alone. One probable explanation is that GHRP-6 is structurally distinct from GHRH and may act as a functional antagonist of somatostatin in the pituitary, making it more likely to have a greater impact on hypothyroidism than GHRH.

GHRP-6 And Hormone Secretion

The potential effects of GHRP-6 peptide on nighttime hormone secretion and electroencephalogram (EEG) sleep were investigated in a recent clinical investigation [vi]. In this study, male test subjects were given either the GHRP-6 peptide or a placebo. Researchers found that GHRP-6 seemed to stimulate greater growth and cortisol (ACTH) hormone production.

While the other sleep EEG variables appeared unchanged, cortisol hormone release and stage 2 sleep appeared to be enhanced throughout the night, especially during the first half. Based on the results of this investigation, it seems that GHRP-6 may work on the hypothalamic-pituitary-adrenal axis to mobilize cortisol hormone release in addition to inducing growth hormone release.

GHRP-6 Peptide and EGF

The primary purpose of this investigation [vii] was to compare the action of GHRP-6 and epidermal growth factor (EGF) on multi-organ dysfunction. This research has been replicated twice: once on experimental damage and multi-organ failure models and once on rat gut and colon cancer cells. The first investigation suggested that GHRP-6 may have affected cell migration in the gut epithelial cells by three times the control rate without affecting cell proliferation.

Lipid peroxidation and severe liver and intestine damage resulted from a multi-organ failure in the second model. It was observed that these damages might be mitigated by 50–85% when GHRP-6 was provided, with even greater activity when GHRP-6 was presented in conjunction with EGF.

Only academic and scientific institutions are allowed to purchase peptides online. If you are a licensed professional interested in purchasing GHRP-6 peptides for your clinical studies, visit Biotech Peptides. Please note that none of the items listed are approved for human or animal consumption. Laboratory research chemicals are only for in-vitro and in-lab use. Any kind of physical introduction is illegal. Only authorized academics and working professionals may make purchases. The content of this article is intended only for instructional purposes.

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